A Robust Approach for Linkage Detection Using Pedigrees

Mutation Analysis of GJB2 and GJB6 Genes and the Genetic Linkage Analysis of Five Common DFNB Loci in the Iranian Families with Autosomal Recessive Non-Syndromic Hearing Loss

The incidence of pre-lingual hearing loss (HL) is about 1 in 1000 neonates. More than 60% of cases are inherited. Non-syndromic HL (NSHL) is extremely heterogeneous: more than 130 loci have been identified so far. The most common form of NSHL is the autosomal recessive form (ARNSHL). In this study, a cohort of 36 big ARNSHL pedigrees with 4 or more patients from 7 provinces of Iran was investig...

Error Detection in Genetic Linkage Data for Human Pedigrees Using Likelihood Ratio Methods

Linkage analysis of extended high-risk pedigrees replicates a cutaneous malignant melanoma predisposition locus on chromosome 9q21

Three predisposition genes have been identified for cutaneous malignant melanoma (CMM), but they account for only ∼25% of melanoma clusters/pedigrees. Linkage analyses of melanoma pedigrees from many countries have failed to identify significant linkage evidence for the remaining predisposition genes that must exist. The Utah linkage analysis approach of using singly informative extended high-r...

Faster linkage analysis computations for pedigrees with loops or unused alleles.

There seems to be no limit to the complexity of computations that genetic linkage analysts want to do. Two primary factors that increase the length of computations are pedigree loops and unknown genotypes. I describe the implementation in FASTLINK of some algorithmic improvements to partly address the problems of pedigree loops and unknown genotypes. LINKAGE is by far the most popular software ...

Robust Fault Detection on Boiler-turbine Unit Actuators Using Dynamic Neural Networks

Due to the important role of the boiler-turbine units in industries and electricity generation, it is important to diagnose different types of faults in different parts of boiler-turbine system. Different parts of a boiler-turbine system like the sensor or actuator or plant can be affected by various types of faults. In this paper, the effects of the occurrence of faults on the actuators are in...